법랑기질 유도체가 치주질환에 이환된 자가이식 치아의 치유에 미치는 영향
The effect of enamel matrix derivative on the healing of autotransplanted periodontally diseased teeth
구강과학- 전남대학교 2001년 13권 1호 p.50 ~ 63
김지환, 김영석, 김지영,
소속 상세정보
김지환 ( ) - 전남대학교 치과대학 치주과학교실
김영석 ( ) - 전남대학교 치과대학 치주과학교실
김지영 ( ) - 전남대학교 치과대학 치주과학교실
KMID : 0988420010130010050
Abstract
The prognosis of transplanted teeth is strongly related with periodontal healing.
Several experimental studies showed that the application of enamel matrix derivatives on periodontitis affected root surfaces resulted in periodontal regeneration.
The purpose of this study was to determine the effect of enamel matrix derivatives on periodontitis affected root surfaces prior to transplantation in dogs.
Class Ⅲ furcation defects were surgically created on the left second, the third and the fourth premolar in the mandibles of nine mongrel dogs and experimental
periodontitis was induced by placing small cotton pellets into defects for 3 weeks.
Periodontitis affected roots were treated by thorough scaling and planing and the coronal portions were removed. Each root was extracted and implanted into recipient bed prepared in the contralateral premolar area. The transplanted roots were grouped according to the treatment modalities; Group Ⅰ roots treated with saline only, Group Ⅱ roots conditioned by neutral EDTA, and Group Ⅲ roots conditioned by neutral EDTA and enamel matrix derivatives (EMDOGAIN^ⓡ, BIORA Co., Sweden).
The animals were sacrificed at 1 weeks, 3 weeks, and 10 weeks after transplantation and decalcified specimens were prepared for histologic examination.
In Group Ⅰ, healing was most frequently characterized by root resorption and
ankylosis. In Group Ⅱ, with root resorption and ankylosis in a few specimens,
connective tissue attachment was partly seen on denuded root surface, but no cementum formation was seen. In Group Ⅲ, there was regeneration by new cementum and periodontal ligament on denuded root surface, although slight root resorption and ankylosis were found in a few specimens.
This results suggests that enamel matrix derivatives treatment of periodontitis affected root surface could reduce the frequency of root resorption and ankylosis and contribute to periodontal regeneration, and might be useful for autologous transplantation.
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